Antitumor agent-59

Names

[ CAS No. ]:
2409952-04-9

[ Name ]:
Antitumor agent-59

Biological Activity

[Description]:

Antitumor agent-59 (Compound 13b) is a potent antitumor agent. Antitumor agent-59 effectively inhibits the proliferation and migration of HCT116 cells. Antitumor agent-59 induces HCT116 cell apoptosis and arrests the cell cycle at the G2/M phase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Antitumor agent-59 (Compound 13b) (72 h) shows antitumor activities with IC50 values of 0.032 ± 0.0071, 0.20 ± 0.020, 0.73 ± 0.12 and 0.58 ± 0.15 μM against HCT116, MCF-7, A549 and HUVEC cells, respectively[1].

[References]

[1]. Liang H, et al. Discovery of novel bis-evodiamine derivatives with potent antitumor activity. Bioorg Med Chem. 2022 Jul 1;65:116793.

Chemical & Physical Properties

[ Molecular Formula ]:
C43H36F2N6O6

[ Molecular Weight ]:
770.78

Related Compounds