Nek2-IN-6

Names

[ CAS No. ]:
2410376-96-2

[ Name ]:
Nek2-IN-6

Biological Activity

[Description]:

Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

Nek2[1]


[In Vitro]

Nek2-IN-6 (Compound 28e) (0-30 μM, 72 h) inhibits tumor cells proliferation[1]. Cell Proliferation Assay[1] Cell Line: MGC-803, Hep-3B, BEL-7402, HCT-116 Concentration: 0-30 μM Incubation Time: 72 h Result: Inhibited cell proliferation with IC50s of 0.038, 1.25, 10.44 and 0.48 μM against MGC-803, Hep-3B, BEL-7402 and HCT-116 cells, respectively.

[References]

[1]. Wang H, et al. Design, synthesis, and structure activity relationship (SAR) studies of novel imidazo[1,2-a] pyridine derivatives as Nek2 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115775.

Chemical & Physical Properties

[ Molecular Formula ]:
C33H33F3N6O4S

[ Molecular Weight ]:
666.71

Related Compounds