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ZLN005-d4

Names

[ CAS No. ]:
2410443-42-2

[ Name ]:
ZLN005-d4

Biological Activity

[Description]:

ZLN005-d4 is deuterium labeled ZLN005. ZLN005 is a potent activator of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)[1].

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Metabolic Disease

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Zhang LN, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62(4):1297-307.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H14D4N2

[ Molecular Weight ]:
254.36

Related Compounds