KRAS inhibitor-20

Names

[ CAS No. ]:
2411786-32-6

[ Name ]:
KRAS inhibitor-20

Biological Activity

[Description]:

KRAS inhibitor-20 is a small molecular inhibitor of KRasG12C, the oncogenic mutant. KRAS inhibitor-20 inhibits KRasG12C with the IC50 value <10 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRAS(G12C):<10 nM (IC50, [1])


[In Vitro]

KRAS inhibitor-20 (compound 12b) results KRasG12C alkylation human lung cancer adenocarcinoma (HCC 1171) with an EC50 value of 3.3 nM[1].

[References]

[1]. Kargbo RB. Small-Molecule Inhibitor of the Oncogenic KRASG12C Mutant for the Treatment of Currently Incurable Cancer. ACS Med Chem Lett. 2022 Apr 20;13(5):767-769. 

Chemical & Physical Properties

[ Molecular Formula ]:
C31H40F4N6O2

[ Molecular Weight ]:
604.68

Related Compounds