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ARUK3001185

Names

[ CAS No. ]:
2411969-39-4

[ Name ]:
ARUK3001185

Biological Activity

[Description]:

ARUK3001185 (Compound 8l) is a potent, selective, orally active and brain-penetrant inhibitor of Notum activity with an IC50 of 6.7 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Stem Cell/Wnt >> Wnt

[Target]

IC50: 6.7 nM (Notum)[1]


[References]

[1]. Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65(10):7212-7230.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H4Cl2F3N3

[ Molecular Weight ]:
282.05

Related Compounds