Thalidomide-5-NH-CH2-COO(t-Bu)
Names
[ CAS No. ]:
2412056-28-9
[ Name ]:
Thalidomide-5-NH-CH2-COO(t-Bu)
[Synonym ]:
Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
Biological Activity
[Description]:
Thalidomide-5-NH-CH2-COO(t-Bu) is a t-Bu modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The t-Bu protecting group at the end of Thalidomide-5-NH-CH2-COO(t-Bu) can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-5-NH-CH2-COO(t-Bu) is a key intermediate in the synthesis of CRBN-based PROTAC molecules.
[Related Catalog]:
Chemical & Physical Properties
[ Molecular Formula ]:
C19H21N3O6
[ Molecular Weight ]:
387.39