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PD-1/PD-L1-IN-13

Names

[ CAS No. ]:
2413100-40-8

[ Name ]:
PD-1/PD-L1-IN-13

Biological Activity

[Description]:

PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8+ T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1

[References]

[1]. Song Z, et al. Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage. J Med Chem. 2021;64(22):16687-16702.

Chemical & Physical Properties

[ Molecular Formula ]:
C36H34ClF2N3O9

[ Molecular Weight ]:
726.12


Related Compounds