MPro Inhibitor 11b

Names

[ Name ]:
MPro Inhibitor 11b

Biological Activity

[Description]:

SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[In Vivo]

SARS-CoV MPro-IN-1 (compound 11b) (5 mg/kg; intravenous drip administration) shows the t1/2 is <1.65 hours and the clearance rate is 20.6 mL/min/mg[1].

[References]

[1]. Dai W, et al. Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. bioRxiv; 2020.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₅FN₄O₄

[ Molecular Weight ]:
464.49

MPro Inhibitor 11b

Names

Biological Activity

Chemical & Physical Properties

Related Compounds