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PDE4-IN-8

Names

[ CAS No. ]:
2415085-45-7

[ Name ]:
PDE4-IN-8

Biological Activity

[Description]:

PDE4-IN-8 (Example 5) is a potent PDE4 inhibitor with an IC50 of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC50=4.04 nM), IL4 (IC50=36.33 nM), IFNy (IC50=2394 nM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Signaling Pathways >> Immunology/Inflammation >> Interleukin Related

[Target]

PDE4B2:0.93 nM (IC50)

IL4:36.33 nM (IC50)

IL-13:4.04 nM (IC50)


[References]

[1]. Joseph Walter Strohbach, et al. Inhibiteurs de pde4 contenant du bore. WO2020070651A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H22BNO4

[ Molecular Weight ]:
327.18

Related Compounds