MYF-01-37
Names
[ CAS No. ]:
2416417-65-5
[ Name ]:
MYF-01-37
Biological Activity
[Description]:
MYF-01-37 is a covalent TEAD inhibitor targeting Cys380. MYF-01-37 has a reversible inhibition on YAP/TEAD interaction[1].
[Related Catalog]:
[In Vitro]
MYF-01-37 (10 μM; 24h) results in inhibition of direct YAP/TEAD interaction in HEK 293T cells, and in the reduction in canonical YAP target gene CTGF expression in PC-9 cells[1]. MYF-01-37 (0.1, 1, 10, 100 μM) has minimal impact on cell viability of several EGFR-mutant NCSLC cell lines[1]. MYF-01-37 (10 μM; 10 days) combinated with OT (combination of osimertinib and trametinib) leads to a dramatic decrease in dormant cells compared to OT alone[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C15H17F3N2O
[ Molecular Weight ]:
298.30
[ Storage condition ]:
-20°C