HIV-1 inhibitor-35

Names

[ CAS No. ]:
2416971-32-7

[ Name ]:
HIV-1 inhibitor-35

Biological Activity

[Description]:

HIV-1 inhibitor-35 (compound 74) is a potent HIV-1 inhibitor with EC50s of 80 nM and 70 nM for LTR and CMV in HEK293 cells, respectively. HIV-1 inhibitor-35 has inhibitory activity against liver cancer cell HepG2 with a CC50 of 40 nM. HIV-1 inhibitor-35 can be used as HIV-1 latency reversing agent[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1[1]


[References]

[1]. Nguyen W, et al. Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents. Eur J Med Chem. 2020;195:112254.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H12Cl3N5OS

[ Molecular Weight ]:
392.69

Related Compounds