(E)-Mcl-1 inhibitor 7

Names

[ CAS No. ]:
2417463-86-4

[ Name ]:
(E)-Mcl-1 inhibitor 7

Biological Activity

[Description]:

(E)-Mcl-1 inhibitor 7 (Example 34) is a Mcl-1 inhibitor (Ki: <1 nM, IC50: <500 nM). (E)-Mcl-1 inhibitor 7 can be used for research of cancers[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Bcl-2 Family
Research Areas >> Cancer

[Target]

Mcl-1:<10 nM (Ki)

Mcl-1:<500 nM (IC50)


[References]

[1]. Zhuo, Jincong, et al. Preparation of spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein for the treatment of cancer. Patent. WO2020097577.

Chemical & Physical Properties

[ Molecular Formula ]:
C34H42ClN3O7S

[ Molecular Weight ]:
672.23

Related Compounds