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(1R,2R)-ML-SI3

Names

[ CAS No. ]:
2418594-00-8

[ Name ]:
(1R,2R)-ML-SI3

Biological Activity

[Description]:

(1R,2R)-ML-SI3 is a potent inhibitor of both TRPML1 and TRPML2 (IC50 values of 1.6 and 2.3 μM) and a weak inhibitor (IC50 12.5 μM) of TRPML3[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

[Target]

TRPML1:1.6 μM (IC50)

TRPML2:2.3 μM (IC50)

TRPML3:12.5 μM (IC50)

[References]

[1]. Leser C, Keller M, Gerndt S, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021;210:112966.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₃₁N₃O₃S

[ Molecular Weight ]:
429.58

Related Compounds