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JKE-1716

Names

[ CAS No. ]:
2421118-05-8

[ Name ]:
JKE-1716

[Synonym ]:
(3Z)-1-{4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}-3-(hydroxyimino)-3-nitro-1-propanone
1,3-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 3-oxime, (3Z)-
JKE-1716

Biological Activity

[Description]:

JKE-1716 is a potent and selective nitrolic acid-containing GPX4 inhibitor. JKE-1716 is able of inducing ferroptosis selectively through covalent GPX4 inhibition[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Apoptosis >> Ferroptosis

[Target]

GPX4[1]; Ferroptosis[1]


[In Vitro]

JKE-1716 (0~100 nΜ; 72 hours; LOX-IMVI cells) inhibits cell viability[1]. JKE-1716 (LOX-IMVI cells) inhibits the expression of α-GPX4[1]. Cell Viability Assay[1] Cell Line: LOX-IMVI cells Concentration: 0~100 nΜ Incubation Time: 72 hours Result: Inhibited cell viability.

[References]

[1]. Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020;16(5):497-506.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
641.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H20Cl2N4O4

[ Molecular Weight ]:
451.303

[ Flash Point ]:
341.5±34.3 °C

[ Exact Mass ]:
450.086151

[ LogP ]:
3.84

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.651

Related Compounds