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Tabimorelin hemifumarate

Names

[ CAS No. ]:
242143-80-2

[ Name ]:
Tabimorelin hemifumarate

[Synonym ]:
D-Phenylalaninamide, N-[(2E)-5-amino-5-methyl-1-oxo-2-hexen-1-yl]-N-methyl-3-(2-naphthalenyl)-D-alanyl-N,Nα-dimethyl-, (2E)-2-butenedioate (2:1)
N-[(2E)-5-Amino-5-methyl-2-hexenoyl]-N-methyl-3-(2-naphthyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide (2E)-2-butenedioate (2:1)
Tabimorelin
N-[(2E)-5-Amino-5-methylhex-2-enoyl]-N-methyl-3-(2-naphthyl)-D-alanyl-N,Nα-dimethyl-D-phenylalaninamide (2E)-but-2-enedioate (2:1)

Biological Activity

[Description]:

Tabimorelin (NN703) hemifumarate is an orally active growth hormone (GH) secretagogue. Tabimorelin hemifumarate is also a potent inhibitor of CYP3A4 activity[1].

[Related Catalog]:

Research Areas >> Endocrinology
Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450

[Target]

CYP3A4


[References]

[1]. Zdravkovic M, et al. A clinical study investigating the pharmacokinetic interaction between NN703 (tabimorelin), a potential inhibitor of CYP3A4 activity, and midazolam, a CYP3A4 substrate. Eur J Clin Pharmacol. 2003 Feb;58(10):683-8.  

Chemical & Physical Properties

[ Molecular Formula ]:
C32H40N4O3.1/2C4H4O4

[ Molecular Weight ]:
586.72

[ Exact Mass ]:
1172.630981

Related Compounds