S1R agonist 1 hydrochloride

Names

[ CAS No. ]:
242487-82-7

[ Name ]:
S1R agonist 1 hydrochloride

Biological Activity

[Description]:

S1R agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist with Kis of 0.93 nM and 72 nM for S1R and S2R, respectively. S1R agonist 1 hydrochloride exhibits neuroprotection against ROS and NMDA-induced neurotoxicity[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

[Target]

Ki: 0.93 nM and 72 nM for S1R and S2R[1]


[References]

[1]. Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.  

Chemical & Physical Properties

[ Molecular Formula ]:
C20H26ClNO

[ Molecular Weight ]:
331.88

Related Compounds