PROTAC STAT3 degrader-2
Names
[ CAS No. ]:
2429877-78-9
[ Name ]:
PROTAC STAT3 degrader-2
Biological Activity
[Description]:
PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research[1].
[Related Catalog]:
[Target]
STAT3:3.54 μM (ID50)
[In Vitro]
PROTAC STAT3 degrader-2 (compound 27; 4 天) 在 Molm-16 具有细胞生长抑制活性,IC50 为 0.582 μM,对 SU-DHL-1 细胞作用低,IC50>10 μM[1]。 PROTAC STAT3 degrader-2 在高达 5 μM 无法降低 SU-DHL-1 细胞中的 STAT3 和 pSTATSY705 蛋白水平[1]。
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C59H60F2N9O13P
[ Molecular Weight ]:
1172.13