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EGFR-IN-69

Names

[ CAS No. ]:
2433837-65-9

[ Name ]:
EGFR-IN-69

Biological Activity

[Description]:

EGFR-IN-69 (compound 17g) is a potent EGFR inhibitor, with IC50 values of 4.3, 6.6 and 25.6 nM against EGFRL858R/T790M/C797S, EGFRL858R/T790M, and EGFR19del/T790M/C797S, respectively. EGFR-IN-69 can be used for non-small-cell-lung-cancer (NSCLC) research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[Target]

EGFR L858R/T790M/C797S:4.3 ± 0.9 nM (IC50)

EGFRL858R/T790M:6.6 ± 0.8 nM (IC50)

EGFRdel19 T790M C797S:25.6 ± 7.5 nM (IC50)

EGFRWT:816.0 ± 82 nM (IC50)


[References]

[1]. Chen H, et al. Conformational Constrained 4-(1-Sulfonyl-3-indol)yl-2-phenylaminopyrimidine Derivatives as New Fourth-Generation Epidermal Growth Factor Receptor Inhibitors Targeting T790M/C797S Mutations. J Med Chem. 2022 May 12;65(9):6840-6858.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H37Cl2N7O3S

[ Molecular Weight ]:
658.64

Related Compounds