Ethyl 4-methoxycinnamate

Names

[ Name ]:
Ethyl 4-methoxycinnamate

[Synonym ]:
2-Propenoic acid, 3-(4-methoxyphenyl)-, ethyl ester, (2E)-
Ferulic acid,ethyl ester
4-Methoxycinnamic Acid Ethyl Ester
ethyl p-methoxycinnamate
3-(4-Methoxyphenyl)acrylic Acid Ethyl Ester
Ethyl (2E)-3-(4-methoxyphenyl)-2-propenoate
Ethyl 4'-hydroxy-3'-methoxycinnamate
p-Methoxycinnamic acid ethyl ester
(E)-Ethyl 3-(4-methoxyphenyl)acrylate
Ethyl 4-MethoxycinnaMate
2-Propenoic acid, 3-(4-methoxyphenyl)-, ethyl ester
ethyl (2E)-3-(4-methoxyphenyl)prop-2-enoate
Ethyl trans-4-methoxycinnamate
Ethyl (2E)-3-(4-methoxyphenyl)acrylate
ethyl ferulate
Ethyl 3-(4-methoxyphenyl)-2-propenoate
Ethyl 3-(4-Methoxyphenyl)acrylate

Biological Activity

[Description]:

(E)-Ethyl p-methoxycinnamate is a natural product found in Kaempferia galangal with anti-inflammatory, anti-neoplastic and anti-microbial effects. (E)-Ethyl p-methoxycinnamate inhibits COX-1 and COX-2 in vitro with IC50s of 1.12 and 0.83 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:1.12 μM (IC50)

COX-2:0.83 μM (IC50)

[References]

[1]. Umar MI, et al. Bioactivity-guided isolation of ethyl-p-methoxycinnamate, an anti-inflammatory constituent, from Kaempferia galangal L. extracts. Molecules. 2012 Jul 23;17(7):8720-34.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
325.1±17.0 °C at 760 mmHg

[ Melting Point ]:
49ºC

[ Molecular Formula ]:
C₁₂H₁₄O₃

[ Molecular Weight ]:
206.238

[ Flash Point ]:
133.8±15.5 °C

[ Exact Mass ]:
206.094299

[ PSA ]:
35.53000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.540

MSDS

Click to get detail MSDS

Safety Information

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2918990090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%