Drometrizole

Names

[ Name ]:
Drometrizole

[Synonym ]:
4-methyl-6-benzotriazol-2-yl-phenol
tinp
UV-P
Porex P
MFCD00022903
2-(2H-Benzo[d][1,2,3]triazol-2-yl)-4-methylphenol
2-(2-Hydroxy-5-Methylphenyl)benzotriazole
2,6-PYRIDINECARBOXALDEHYDE
Uvazol P
Ultraviolet Absorbent UV-P
TINUVIN P
ThasorbUvp
Drometrizole
Benazol II
2-(2-Benzotriazolyl)-p-cresol
2-(-Hydroxy-5-methylphenyl)benzo triazole
EINECS 219-470-5

Biological Activity

[Description]:

Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Lee JK, et al. Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber. Toxicol Res. 2019;35(2):119-129.

Chemical & Physical Properties

[ Density]:
1.38

[ Boiling Point ]:
276.1ºC at 760mmHg

[ Melting Point ]:
125.5-129.5 °C(lit.)

[ Molecular Formula ]:
C₁₃H₁₁N₃O

[ Molecular Weight ]:
225.24600

[ Flash Point ]:
133.9ºC

[ Exact Mass ]:
225.09000

[ PSA ]:
50.94000

[ LogP ]:
2.43450

[ Vapour Pressure ]:
4.81E-07mmHg at 25°C

[ Index of Refraction ]:
1.765

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GO6860000

CHEMICAL NAME :: p-Cresol, 2-(2H-benzotriazol-2-yl)-

CAS REGISTRY NUMBER :: 2440-22-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H11-N3-O

MOLECULAR WEIGHT :: 225.27

WISWESSER LINE NOTATION :: T56 BNNNJ CR BQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,835,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(3),49,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9391 No. of Facilities: 2261 (estimated) No. of Industries: 23 No. of Occupations: 37 No. of Employees: 52370 (estimated) No. of Female Employees: 21694 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
1

[ RTECS ]:
GO6860000

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%