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monomethyl kolavate

Names

[ CAS No. ]:
24513-41-5

[ Name ]:
monomethyl kolavate

[Synonym ]:
Haplopappsaeure
Kolavinsaeure
1-Naphthalenecarboxylic acid, 3,4,4a,5,6,7,8,8a-octahydro-5-[(3E)-5-methoxy-3-methyl-5-oxo-3-penten-1-yl]-5,6,8a-trimethyl-, (4aR,5S,6R,8aR)-
Glutinic acid
kolavic acid 15-monomethyl ester
Kolavinsaeure-methylester
(4aR,5S,6R,8aR)-5-[(3E)-5-Methoxy-3-methyl-5-oxo-3-penten-1-yl]-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-1-naphthalenecarboxylic acid

Biological Activity

[Description]:

Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC50 value of 2 µM[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Fabian C Herrmann, et al. In Silico Identification and in Vitro Activity of Novel Natural Inhibitors of Trypanosoma brucei Glyceraldehyde-3-phosphate-dehydrogenase. Molecules. 2015 Sep 3;20(9):16154-69.   

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
456.6±18.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H32O4

[ Molecular Weight ]:
348.48

[ Flash Point ]:
150.4±14.7 °C

[ Exact Mass ]:
348.230072

[ PSA ]:
63.60000

[ LogP ]:
6.59

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.502

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds