EtDO-P4

Names

[ Name ]:
EtDO-P4

[Synonym ]:
D-threo-1-(3',4'-Ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol
Hexadecanamide,N-[(1R,2R)-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]

Biological Activity

[Description]:

EtDO-P4 is a nanomolar inhibitor of glycosphingolipid (GSL) synthesis. EtDO-P4 suppresses activation of the EGFR-induced ERK pathway and various receptor tyrosine kinases (RTKs). EtDO-P4 can be used for various types of cancer, including Burkitt’s lymphoma[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Seung-Yeol Park, et al. Globoside promotes activation of ERK by interaction with the epidermal growth factor receptor. Biochim Biophys Acta. 2012 Jul;1820(7):1141-8.

Chemical & Physical Properties

[ Density]:
1.05g/cm3

[ Boiling Point ]:
684.419ºC at 760 mmHg

[ Molecular Formula ]:
C₃₁H₅₂N₂O₄

[ Molecular Weight ]:
516.75600

[ Flash Point ]:
367.723ºC

[ Exact Mass ]:
516.39300

[ PSA ]:
71.03000

[ LogP ]:
6.88190

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.524

EtDO-P4

Names

Biological Activity

Chemical & Physical Properties

Related Compounds