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L6H21

Names

[ CAS No. ]:
24533-47-9

[ Name ]:
L6H21

Biological Activity

[Description]:

L6H21, a derivative of chalcone, is an orally active and potent MD-2 (myeloid differentiation factor 2) inhibitor. L6H21 inhibits TLR4-NF-κB signaling and NLRP3 inflammasome activation in macrophages. L6H21 inhibits EtOH + LPS-induced apoptosis and mitochondrial damage in RAW264.7 cells. L6H21 effectively inhibits EtOH + LPS-induced hepatic fat accumulation and liver injury. L6H21 shows neuroprotective effect in a model of prediabetes[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Research Areas >> Neurological Disease

[References]

[1]. Kong X, et al. Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation. Alcohol Clin Exp Res. 2019 Aug;43(8):1662-1671.

[2]. Oo TT, et al. L6H21 protects against cognitive impairment and brain pathologies via toll-like receptor 4-myeloid differentiation factor 2 signalling in prediabetic rats. Br J Pharmacol. 2022 Mar;179(6):1220-1236.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H18O4

[ Molecular Weight ]:
298.33

Related Compounds