HIV-1 inhibitor-42

Names

[ CAS No. ]:
2459929-46-3

[ Name ]:
HIV-1 inhibitor-42

Biological Activity

[Description]:

HIV-1 inhibitor-42 (compound 5b) is a potent HIV-1 inhibitor, with an IC50 of 0.06 μM. HIV-1 inhibitor-42 inhibits HIV-1 RT RNA-dependent DNA polymerase and DNA-dependent DNA polymerase, with IC50 values of 0.518 and 0.072 μM[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1:0.06 ± 0.0 μM (IC50)

HIV-1 (Y181C):15.510 ± 1 μM (IC50)

HIV-1 (K103N):53.045 ± 6 μM (IC50)


[References]

[1]. Yi-MingLi, et al. Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs. September 2020;102:104041.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H20N2O5S

[ Molecular Weight ]:
424.47

Related Compounds