HIV-IN-5

Names

[ CAS No. ]:
2459929-62-3

[ Name ]:
HIV-IN-5

Biological Activity

[Description]:

HIV-IN-5 (compound 5r) is a potent HIV-1 inhibitor, with an IC50 of 0.16 μM. HIV-IN-5 shows inhibition of HIV DNA-dependent DNA polymerization activity, with an IC50 of 2.18 μM. HIV-IN-5 can bind to NNIBP (NNRTIs (non-nucleoside reverse transcriptase inhibitors) binding pocket) [1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1:0.16 ± 0.0 μM (IC50)

HIV-1 (Y181C):>100 μM (IC50)

HIV-1 (K103N):>100 μM (IC50)


[References]

[1]. Yi-MingLi, et al. Design, synthesis and anti-HIV evaluation of 5-alkyl- 6-(benzo[d][1,3]dioxol-5-alkyl)-2-mercaptopyrimidin-4(3H)-ones as potent HIV-1 NNRTIs. September 2020;102:104041.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H24N2O8S

[ Molecular Weight ]:
572.59

Related Compounds