Antitumor agent-62

Names

[ CAS No. ]:
2460735-29-7

[ Name ]:
Antitumor agent-62

Biological Activity

[Description]:

Antitumor agent-62 (Compound 47) is a NO-releasing antitumor agent. Antitumor agent-62 shows antiproliferative activity against four cancer cell lines. Antitumor agent-62 activates mitochondrial apoptosis pathway and arrests cell cycle at G2/M phase[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Antitumor agent-62 (Compound 47) shows antiproliferative activity with IC50 values of 1.23 ± 0.10, 1.91 ± 0.14, 2.81 ± 0.13, 4.18 ± 0.15 and 9.16 ± 0.38 μM against MDA-MB-231, MCF-7, HepG2, A549 and LO2 cells, respectively[1].

[References]

[1]. Shi Z, et al. Novel NO-releasing scopoletin derivatives induce cell death via mitochondrial apoptosis pathway and cell cycle arrest. Eur J Med Chem. 2020 Aug 15;200:112386.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H19N3O9S

[ Molecular Weight ]:
489.46

Related Compounds