Gefitinib impurity 2
Names
[ CAS No. ]:
246512-44-7
[ Name ]:
Gefitinib impurity 2
[Synonym ]:
2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide
Biological Activity
[Description]:
Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C15H23N3O4
[ Molecular Weight ]:
309.36100
[ Exact Mass ]:
309.16900
[ PSA ]:
101.03000
[ LogP ]:
1.88070