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Gefitinib impurity 2

Names

[ CAS No. ]:
246512-44-7

[ Name ]:
Gefitinib impurity 2

[Synonym ]:
2-aMino-4-Methoxy-5-(3-Morpholinopropoxy)benzaMide

Biological Activity

[Description]:

Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Wakeling AE, et al. ZD1839: an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Res. 2002 Oct 15;62(20):5749-54.

[2]. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H23N3O4

[ Molecular Weight ]:
309.36100

[ Exact Mass ]:
309.16900

[ PSA ]:
101.03000

[ LogP ]:
1.88070

Synthetic Route

Precursor & DownStream


Related Compounds