Thalidomide-O-amido-C11-COOH

Names

[ CAS No. ]:
2473270-96-9

[ Name ]:
Thalidomide-O-amido-C11-COOH

Biological Activity

[Description]:

Thalidomide-O-amido-C11-COOH (compound IMiD acid 1) is an E3 ligase ligand and linker CRBN (Cereblon) conjugate. Thalidomide-O-amido-C11-COOH can be used to synthesize PROTAC that target the degradation of DOT1L[1].

[Related Catalog]:

Signaling Pathways >> PROTAC >> PROTAC-linker Conjugate for PAC
Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> PROTAC-linker Conjugate for PAC

[References]

[1]. Jun Qi, et al. Small molecules for dot1l degradation and uses thereof. Patent WO2023069348A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H35N3O8

[ Molecular Weight ]:
529.58

Related Compounds