SB 328437

Names

[ Name ]:
SB 328437

[Synonym ]:
L-Phenylalanine,N-(1-naphthalenylcarbonyl)-4-nitro-,methyl ester
(S)-Methyl-2-naphthoylamino-3-(4-nitrophenyl)propionate
N-(1-NAPHTHALENYLCARBONYL)-4-NITRO-L-PHENYLALANINE METHYL ESTER
L-Phenylalanine (N-(1-naphthalenylcarbonyl)-4-nitro

Biological Activity

[Description]:

SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> CCR

Signaling Pathways >> Immunology/Inflammation >> CCR

Research Areas >> Inflammation/Immunology

[Target]

CCR3:4.5 nM (IC50)

[References]

[1]. White JR, et al. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J Biol Chem. 2000 Nov 24;275(47):36626-31.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₈N₂O₅

[ Molecular Weight ]:
378.37800

[ Exact Mass ]:
378.12200

[ PSA ]:
104.71000

[ LogP ]:
4.36010

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

CCR3 antagonists: a survey of the patent literature.

Expert Opin. Ther. Pat. 19(8) , 1109-32, (2009)

Since the mid-1990s, there has been significant effort invested in the discovery and clinical development of CC chemokine receptor-3 (CCR3) antagonists as potential therapeutics for airway disease.A p...

Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.

Int. Immunol. 19(8) , 913-21, (2007)

The effects of selective CC chemokine receptor (CCR)-3 antagonists on antigen-induced leukocyte accumulation in the lungs of mice adoptively transferred with in vitro-differentiated T(h)1 and T(h)2 we...

CCR3 and choroidal neovascularization.

PLoS ONE 6 , e17106, (2011)

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly in industrialized countries. The "wet" AMD, characterized by the development of choroidal neovacula...