Angiopeptin TFA
Names
[ CAS No. ]:
2478421-60-0
[ Name ]:
Angiopeptin TFA
Biological Activity
[Description]:
Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, a weak sst2/sst5 receptor partial agonist with IC50 values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibit adenylate cyclase or stimulate extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research[1][2].
[Related Catalog]:
[Target]
IC50: 0.26 nM (sst2) and 6.92 nM (sst5)[1][2]
[In Vitro]
Angiopeptin (0.1 nM- 10 μM; for 1 h) TFA acts as a partial agonist (pEC50=6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst2 cells[2].
[In Vivo]
Angiopeptin (20 and 50μg/kg; i.h.) TFA significantly inhibits neointimal formation[1]. Angiopeptin (20 μg/kg; per day) TFA significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C58H73F6N11O14S2
[ Molecular Weight ]:
1326.39