BACE1-IN-12

Names

[ CAS No. ]:
2479315-19-8

[ Name ]:
BACE1-IN-12

Biological Activity

[Description]:

BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH). BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Beta-secretase
Research Areas >> Neurological Disease

[Target]

IC50: 8.9 ± 0.20 µM (BACE1), 3.2 ± 0.2 µM (BuChE)[1]


[References]

[1]. Haghighijoo Z, et al. N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104146.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H28Cl2N6O

[ Molecular Weight ]:
547.48

Related Compounds