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(Phe2,Orn8)-Oxytocin trifluoroacetate salt

Names

[ CAS No. ]:
2480-41-3

[ Name ]:
(Phe2,Orn8)-Oxytocin trifluoroacetate salt

[Synonym ]:
H-CYS-PHE-ILE-GLN-ASN-CYS-PRO-ORN-GLY-NH2,(DISULFIDE BOND)
(PHE2,ORN8)-OXYTOCIN
[Phe2,Orn8]OT
CYS-PHE-ILE-GLN-ASN-CYS-PRO-ORN-GLY-NH2
(PHE2,ILE3,ORN8)-VASOPRESSIN
H-CYS-PHE-ILE-GLN-ASN-CYS-PRO-ORN-GLY-NH2
oxytocin,Phe(2)-Orn(8)
[PHE2,ORN8] VASOTOCIN
Glycinamide, 1-[[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-16-(phenylmethyl)-1,2-dithia-5,8,11,14,17-pentaazacycloeicos-4-yl]carbonyl]-L-prolyl-L-ornithyl-
1-({(4R,7S,10S,13S,16S,19R)-19-Amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-benzyl-13-[(2S)-2-butanyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-ornithylglycinamide
(Phe2,Orn8)-Oxytocin (Phe2,Ile3,Orn8)-Vasopressin
CYS-PHE-ILE-GLN-ASN-CYS-PRO-ORN-GLY-NH2 (DISULFIDE BRIDGE:CYS1-CYS6)
2-L-Phenylalanine-8-L-ornithine-oxytocin

Biological Activity

[Description]:

(Phe2,Orn8)-Oxytocin is a selective V1 vasopressin agonist. (Phe2,Orn8)-Oxytocin induces a sustained contractility of rabbit epididymis with EC50 value of 280 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Vasopressin Receptor
Research Areas >> Neurological Disease

[References]

[1]. Sandra Filippi, et al. Estrogens, But Not Androgens, Regulate Expression and Functional Activity of Oxytocin Receptor in Rabbit Epididymis. Endocrinology. 2002, 4271-4280.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
1536.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C42H65N13O11S2

[ Molecular Weight ]:
992.176

[ Flash Point ]:
883.2±34.3 °C

[ Exact Mass ]:
991.436768

[ PSA ]:
455.92000

[ LogP ]:
-5.21

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.556

[ Water Solubility ]:
Slightly soluble (7.8 g/L) (25 ºC)

Related Compounds