Thiol-PEG5-alcohol

Names

[ CAS No. ]:
248582-03-8

[ Name ]:
Thiol-PEG5-alcohol

[Synonym ]:
2-[2-[2-[2-(2-sulfanylethoxy)ethoxy]ethoxy]ethoxy]ethanol
HS-PEG5-OH

Biological Activity

[Description]:

Thiol-PEG5-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₂₂O₅S

[ Molecular Weight ]:
254.341

Thiol-PEG5-alcohol

Names

Biological Activity

Chemical & Physical Properties

Related Compounds