Thalidomide-4-NH-PEG1-NH2 TFA

Names

[ Name ]:
Thalidomide-4-NH-PEG1-NH2 TFA

[Synonym ]:
1h-isoindole-1,3(2h)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-, 2,2,2-tr

Biological Activity

[Description]:

Thalidomide-4-NH-PEG1-NH2 TFA is an E3 Ligase Ligand-Linker Conjugate consisting of Thalidomide (HY-14658) and NH-PEG3-NH-Boc. Thalidomide-4-NH-PEG1-NH2 TFA acts as a ligand for Cereblon to recruit CRBN protein. Thalidomide-4-NH-PEG1-NH2 TFA is a key intermediate in the synthesis of CRBN-based PROTAC molecules.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₁F₃N₄O₇

[ Molecular Weight ]:
474.39