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FTX-6058

Names

[ CAS No. ]:
2490676-18-9

[ Name ]:
FTX-6058

Biological Activity

[Description]:

FTX-6058 is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). FTX-6058 can induce HbF protein expression in cell and murine models. FTX-6058 can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Epigenetics >> Histone Methyltransferase

[In Vitro]

FTX-6058 inhibits PRC2 via binding to EED, which induces robust HbF protein expression in both cell and murine models[2].

[References]

[1]. Boerner LK. Virtual meeting delivers first time drug structures. April 12, 2021.

[2]. Fulcrum Therapeutics Presents Published Structure of Investigational Small Molecule FTX-6058 at the American Chemical Society (ACS) Spring 2021 Virtual Conference.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H18FN5O2

[ Molecular Weight ]:
403.41

Related Compounds