2,5-Cyclohexadiene-1,4-dione,2,5-bis(4-ethylphenyl)-3,6-dihydroxy-

Names

[ Name ]:
2,5-Cyclohexadiene-1,4-dione,2,5-bis(4-ethylphenyl)-3,6-dihydroxy-

[Synonym ]:
2,5-Bis-(p-ethylphenyl)-3,6-dihydroxy-p-benzochinon
p-Benzoquinone,2,5-bis(p-ethylphenyl)-3,6-dihydroxy

Biological Activity

[Description]:

NSC114126 is a potent and orally active inhibitor of EGFR tyrosine kinase (EGFR-TK). NSC114126 has strong antiproliferative activities. NSC114126 has the potential for the research of cancer diseases[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> EGFR

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR

[References]

[1]. Jiwacharoenchai N, et al. Discovery of potent antiproliferative agents from selected oxygen heterocycles as EGFR tyrosine kinase inhibitors from the U.S. National Cancer Institute database by in silico screening and bioactivity evaluation. Bioorg Med Chem Lett. 2022;58:128524.

Chemical & Physical Properties

[ Density]:
1.309g/cm3

[ Boiling Point ]:
555.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₀O₄

[ Molecular Weight ]:
348.39200

[ Flash Point ]:
303.7ºC

[ Exact Mass ]:
348.13600

[ PSA ]:
74.60000

[ LogP ]:
4.20160

[ Vapour Pressure ]:
3.66E-13mmHg at 25°C

[ Index of Refraction ]:
1.66

2,5-Cyclohexadiene-1,4-dione,2,5-bis(4-ethylphenyl)-3,6-dihydroxy-

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds