Dyrk1A-IN-3

Names

[ CAS No. ]:
2493976-27-3

[ Name ]:
Dyrk1A-IN-3

Biological Activity

[Description]:

Dyrk1A-IN-3 (Compound 8b), a highly selective  dual-specificity tyrosine-regulated kinase 1A (DYRK1A) inhibitor, maintains high levels of DYRK1A binding affinity (IC50=76 nM). Dyrk1A-IN-3 can be used for the research of neurodegenerative disorders such as Alzheimer’s Disease, Huntington’s Disease, and Parkinson’s Disease[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK
Research Areas >> Neurological Disease

[References]

[1]. Scott H Henderson, et al. Mining Public Domain Data to Develop Selective DYRK1A Inhibitors. ACS Med Chem Lett. 2020 Jun 30;11(8):1620-1626.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H16N6

[ Molecular Weight ]:
316.36

Related Compounds