4-Aminobenzamidine dihydrochloride
Names
[ CAS No. ]:
2498-50-2
[ Name ]:
4-Aminobenzamidine dihydrochloride
[Synonym ]:
4-AMBA dihydrochloride
Benzenecarboximidamide, 4-amino-, hydrochloride (1:2)
4-aminobenzimidamide dihydrochloride
4-aminobenzimidine dihydrochloride
MFCD00013001
4-aminobenzoamidine dihydrochloride
P-AMINOBENZAMIDINE DIHCL
4-AMINOBENZAMIDINE 2HCL
Benzenecarboximidamide,4-amino-,dihydrochloride
4-Aminobenzenecarboximidamide dihydrochloride
p-Aminobenzamidine dihydrochloride
Benzamidine,p-amino-,dihydrochloride
EINECS 219-692-2
4-Aminobenzamidine Dihydrochloride
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Trypsin[1] Ki: 82 μM (uPA)[1]
[References]
Chemical & Physical Properties
[ Density]:
1.26g/cm3
[ Boiling Point ]:
289.8ºC at 760 mmHg
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C7H11Cl2N3
[ Molecular Weight ]:
208.088
[ Flash Point ]:
129ºC
[ Exact Mass ]:
207.033005
[ PSA ]:
75.89000
[ LogP ]:
3.53810
[ Vapour Pressure ]:
0.00216mmHg at 25°C
[ Storage condition ]:
2-8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CV6126500
- CHEMICAL NAME :
- Benzamidine, p-amino-, dihydrochloride
- CAS REGISTRY NUMBER :
- 2498-50-2
- LAST UPDATED :
- 199007
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C7-H9-N3.2Cl-H
- MOLECULAR WEIGHT :
- 208.11
- WISWESSER LINE NOTATION :
- ZR DYZUM &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Brain and Coverings - meningeal changes Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 20,1045,1979
Safety Information
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S37/39
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
CV6126500
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Articles
Biochem. Biophys. Res. Commun. 457(3) , 358-62, (2015)
The potent fibrinolytic enzyme, plasmin has numerous clinical applications for recannulizing vessels obstructed by thrombus. Despite its diminutive size, 91 kDa, success in the recombinant expression ...
p-Aminobenzamidine as a fluorescent probe for the active site of serine proteases.J. Biol. Chem. 257 , 3014, (1982)
p-Aminobenzamidine is weakly fluorescent in neutral aqueous buffer, with excitation and emission maxima at 293 and 376 nm, respectively. Binding to trypsin results in a blue shift of the emission peak...
Comparative studies on the inhibition of trypsin, plasmin, and thrombin by derivatives of benzylamine and benzamidine.Eur. J. Biochem. 6 , 502, (1968)