Cyclic Arg-Gly-Asp-D-Tyr-Lys

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

Signaling Pathways >> Cytoskeleton >> Integrin

Research Areas >> Cancer

IC50: 20 nM (αVβ3 Integrin), 3000 nM (αIIbβ3 Integrin), 4000 nM (αVβ5 Integrin)[1]

Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM)[1].

[1]. Haubner R, et al. Glycosylated RGD-containing peptides: tracer for tumor targeting and angiogenesis imaging with improved biokinetics. J Nucl Med. 2001 Feb;42(2):326-36.

Cilengitide | Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate salt | Arg-Gly-Asp-Ser | CWHM-12 | OSU-T315 | E 7820 | GLPG 0187 | Firategrast | ATN-161 trifluoroacetate salt | Cucurbitacin B | Eptifibatide acetate salt | iRGD peptide | Lifitegrast | Zaurategrast | Integrin Antagonist 1 (hydrochloride)