Poly(1-vinylpyrrolidone-co-vinyl acetate)

Names

[ Name ]:
Poly(1-vinylpyrrolidone-co-vinyl acetate)

[Synonym ]:
copolyvidone
kolima35
gaf-s630
Cholest-8(14)-ene-3,6-diyl diacetate
kolima10
s630
Cholest-8(14)-ene-3,6-diol, diacetate
MFCD00134018
pvp-va
VP/VA Copolymers Powder

Biological Activity

[Description]:

Copovidone can be used as an excipient, such as Film formers, adhesives, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
536.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
(C₆H₉NO_.C₄H₆O₂)n

[ Molecular Weight ]:
486.726

[ Flash Point ]:
254.7±28.5 °C

[ Exact Mass ]:
486.370911

[ PSA ]:
46.61000

[ LogP ]:
9.76

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.517

[ Stability ]:
Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AH3539000

CHEMICAL NAME :: Acetic acid, ethenyl ester, polymer with 1-ethenyl-2-pyrrolidinone

CAS REGISTRY NUMBER :: 25086-89-9

LAST UPDATED :: 199710

DATA ITEMS CITED :: 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >630 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(5),141,1983

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R10

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
UN 1987 3/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
AH3539000

[ Packaging Group ]:
II

[ Hazard Class ]:
3.0