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PDE4-IN-9

Names

[ CAS No. ]:
2519450-32-7

[ Name ]:
PDE4-IN-9

Biological Activity

[Description]:

PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[References]

[1]. Lin Y, et al. Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors. Eur J Med Chem. 2020 Dec 1;207:112795.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H12N4O3S

[ Molecular Weight ]:
328.35

Related Compounds