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Biotin-PEG3-acid

Names

[ CAS No. ]:
252881-76-8

[ Name ]:
Biotin-PEG3-acid

[Synonym ]:
4,7,10-Trioxa-13-azaoctadecan-1-oic acid, 18-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-14-oxo-
MFCD22574817
14-Oxo-18-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10-trioxa-13-azaoctadecan-1-oic acid

Biological Activity

[Description]:

Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
770.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H33N3O7S

[ Molecular Weight ]:
447.546

[ Flash Point ]:
419.9±32.9 °C

[ Exact Mass ]:
447.203918

[ LogP ]:
-1.40

[ Vapour Pressure ]:
0.0±5.7 mmHg at 25°C

[ Index of Refraction ]:
1.520

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds