COX-2-IN-20

Names

[ CAS No. ]:
2529451-43-0

[ Name ]:
COX-2-IN-20

Biological Activity

[Description]:

COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-2:17.9 nM (IC50)

COX-1:19.3 μM (IC50)


[In Vitro]

COX-2-IN-20 (Compound 5d) shows potential anti-inflammatory activity on NO inhibition in LPS-induced RAW 264.7 cell with an IC50 of 2.87 μM[1].

[In Vivo]

COX-2-IN-20 (Compound 5d) (5 mg/kg) exhibits better in vivo anti-inflammation and gastric protection than 10 mg/kg Indomethacin[1].

[References]

[1]. Li SM, et al. New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study. Bioorg Chem. 2020 Nov;104:104333.

Chemical & Physical Properties

[ Molecular Formula ]:
C11H9ClFN3O2

[ Molecular Weight ]:
269.66

Related Compounds