1-(2-(trifluoromethyl)phenyl)-1h-imidazole

Names

[ Name ]:
1-(2-(trifluoromethyl)phenyl)-1h-imidazole

[Synonym ]:
1-[2-(Trifluoromethyl)phenyl]-1H-imidazole
1-(2-(trifluoromethyl)phenyl)-1h-imidazole
1-[2-(Trifluoromethyl)phenyl]imidazole
Trim
MFCD00041206
1H-Imidazole, 1-[2-(trifluoromethyl)phenyl]-
1H-Imidazole, 1-(2-(trifluoromethyl)phenyl)-

Biological Activity

[Description]:

TRIM is a potent nitric oxide synthase inhibitor. TRIM inhibits mouse cerebellar nNOS and rat lung iNOS in vitro with IC50 values of 28.2 and 27.0 µM, respectively. Antidepressant- and anxiolytic-like effects[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Neurological Disease

[In Vitro]

TRIM is a relatively weak inhibitor of eNOS (IC50, 1057.5 µM)[1].

[References]

[1]. Handy RL, et al. The antinociceptive effect of 1-(2-trifluoromethylphenyl) imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse. Br J Pharmacol. 1995;116(5):2349-2350.

[2]. Volke V, et al. Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2-trifluoromethylphenyl)-imidazole in mice. Behav Brain Res. 2003;140(1-2):141-147.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
288.3±40.0 °C at 760 mmHg

[ Melting Point ]:
43 °C

[ Molecular Formula ]:
C₁₀H₇F₃N₂

[ Molecular Weight ]:
212.171

[ Flash Point ]:
128.2±27.3 °C

[ Exact Mass ]:
212.056137

[ PSA ]:
17.82000

[ LogP ]:
2.55

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.522

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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