P2X3 antagonist 38

Names

[ CAS No. ]:
2545974-71-6

[ Name ]:
P2X3 antagonist 38

Biological Activity

[Description]:

P2X3 antagonist 38 (compound 4) is a potent and orally active P2X3 antagonist with IC50 values of 0.132, 0.165, 0.421 µM for hP2X3, rP2X3, gpP2X3, respectively[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor

[Target]

P2X3 Receptor:0.132 μM (IC50)


[References]

[1]. YunFeng Chen, et al. N-carboxamidopyrazoline derivative serving as p2x3 receptor antagonist and applications. WO2022028154A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H25F3N6O3

[ Molecular Weight ]:
478.47

Related Compounds