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Alovudine

Names

[ CAS No. ]:
25526-93-6

[ Name ]:
Alovudine

[Synonym ]:
MFCD00056058
3,-Deoxy-3,-fluoro Thymidine
Thymidine, 3'-deoxy-3'-fluoro-
Alovudine

Biological Activity

[Description]:

3'-Fluoro-3'-deoxythymidine (Alovudine) is a marker of DNA synthesis that is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Challapalli A, et al. 3'-Deoxy-3'-18F-fluorothymidine positron emission tomography as an early predictor of disease progression in patients with advanced and metastatic pancreatic cancer. Eur J Nucl Med Mol Imaging. 2015 May;42(6):831-40.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Melting Point ]:
176-178ºC(lit.)

[ Molecular Formula ]:
C10H13FN2O4

[ Molecular Weight ]:
244.22

[ Exact Mass ]:
244.085938

[ PSA ]:
84.32000

[ LogP ]:
-0.52

[ Index of Refraction ]:
1.565

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XP2073000
CHEMICAL NAME :
Thymidine, 3'-deoxy-3'-fluoro-
CAS REGISTRY NUMBER :
25526-93-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H13-F-N2-O4
MOLECULAR WEIGHT :
244.25
WISWESSER LINE NOTATION :
T6NVMVJ E1 A- ET5OTJ B1Q CF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - mouse Ascites tumor
DOSE/DURATION :
10 umol/L
REFERENCE :
PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 32,178,1977

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds