HIV-1 inhibitor-21
Names
[ CAS No. ]:
2554620-04-9
[ Name ]:
HIV-1 inhibitor-21
Biological Activity
[Description]:
HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM)[1].
[Related Catalog]:
[Target]
HIV-1 (WT):12.7 nM (EC50)
HIV-1 (K103N):10.4 nM (EC50)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C28H24N6O2
[ Molecular Weight ]:
476.53