HIV-1 inhibitor-23

Names

[ CAS No. ]:
2554622-28-3

[ Name ]:
HIV-1 inhibitor-23

Biological Activity

[Description]:

HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1 (WT):24.9 nM (EC50)

HIV-1 (K103N):10.4 nM (EC50)


[References]

[1]. Han S, et al. Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. Eur J Med Chem. 2020;185:111874.

Chemical & Physical Properties

[ Molecular Formula ]:
C30H26N6O4S

[ Molecular Weight ]:
566.63


Related Compounds