ABCG2-IN-1

Names

[ CAS No. ]:
2559759-40-7

[ Name ]:
ABCG2-IN-1

Biological Activity

[Description]:

ABCG2-IN-1 (compound K2), a Ko143 analog, is an orally active ABCG2 inhibitor with an IC50 of 0.13 μM. ABCG2-IN-1 has favorable oral pharmacokinetic profiles in mice[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> BCRP

[Target]

IC50: 0.13 μM (ABCG2)[1]


[References]

[1]. Junjie Zhu, et al. Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors. Eur J Med Chem. 2023 Nov 5;259:115666.  

Chemical & Physical Properties

[ Molecular Formula ]:
C26H36N4O4

[ Molecular Weight ]:
468.59

Related Compounds