Adenylyl Imidodiphosphate

Names

[ CAS No. ]:
25612-73-1

[ Name ]:
Adenylyl Imidodiphosphate

[Synonym ]:
Adenosine beta,gamma-imidotriphosphate

Biological Activity

[Description]:

AMP-PNP (Adenylyl imidodiphosphate) is a non-hydrolysable ATP analogue[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

AMP-PNP binding induces an inward rotation and shift of the transmembrane helices of LptFG and LptC to tighten the cavity, with the closure of two lateral gates, to eventually expel LPS into the bridge[1]. AMP-PNP significantly inhibits the ATPase activity of sfLptB2FGC, which was used to mimic and lock an ATP-bound state of sfLptB2FGC[1].

[References]

[1]. Tang X, et al. Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism. Nat Commun. 2019 Sep 13;10(1):4175.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₇N₆O₁₂P₃

[ Molecular Weight ]:
506.19600

[ Exact Mass ]:
506.01200

[ PSA ]:
311.36000

Adenylyl Imidodiphosphate

Names

Biological Activity

Chemical & Physical Properties

MSDS

Click to get detail MSDS

Related Compounds